PPP1R15A

Across TCGA patient cohorts, PPP1R15A RNA expression is significantly associated with the protein abundance of many other proteins, with 15,261 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPP1R15A-associated proteins across cancer lineages are MAP7D1_S70, PPP1R12A_S995, and ZFP36_S186. Each is linked with PPP1R15A in more than 6 cancer types. Because this analysis shows association rather than direction, both PPP1R15A-to-partner and partner-to-PPP1R15A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP1R15A versus MAP7D1_S70 in LSCC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R15A→partner) and Y-score (partner→PPP1R15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP7D1_S70 →	+0.581	+0.954	<.001	<.001	3	7
GBM	PPP1R12A_S995 →	+0.680	+0.848	.001	<.001	3	7
OV	ZFP36_S186 →	+0.956	+0.740	<.001	.002	3	7
HNSC	ARHGEF40_S262 →	-0.950	-1.309	.007	.006	3	7
GBM	C4BPB →	+0.853	+0.994	<.001	<.001	3	7
BRCA	KLKB1 →	+0.609	+0.757	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,261 associations by consensus.

PPP1R15A vs MAP7D1_S70 — LSCC

Explore this scatter interactively →