PPP1R15A

Across TCGA pan-cancer cohorts, PPP1R15A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PPP1R15A data layer compared with 2 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PPP1R15A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R15A expression acts as an unfavorable survival marker, although some lineages such as UCEC and CHOL show a favorable association.

LGG, MESO, and ESCA are the cancer types where PPP1R15A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.642	0.833	<.001	54	view →
MESO	OS	Tertile	II,III,IV	0.271	0.582	<.001	50	view →
ESCA	OS	Median	II,III,IV	0.342	0.621	.002	30	view →
OV	DFS	Quartile	III,IV	0.437	0.579	.004	28	view →
ACC	DFS	Tertile	All	0.491	0.761	.007	28	view →
UCEC	DFS	Quartile	II,III,IV	0.905	0.724	.004	26	view →
THCA	OS	Median	II,III,IV	0.792	1.000	.004	23	view →
PAAD	OS	Median	All	0.387	0.628	.009	20	view →
CHOL	OS	Tertile	All	1.000	0.180	.008	18	view →
COAD	DFS	Tertile	All	0.731	0.855	.011	13	view →
SKCM	OS	Quartile	II,III,IV	0.933	0.822	.003	11	view →
SARC	DFS	Median	All	0.422	0.631	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PPP1R15A–LGG (DFS)

Open the LGG breakdown →