PPP1R15A

Across TCGA patient cohorts, PPP1R15A mutation is significantly associated with the RNA expression of many other genes, with 2,373 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R15A-associated genes across cancer lineages are HSBP1P2, SKA1, and EME1. Each is linked with PPP1R15A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R15A-to-partner and partner-to-PPP1R15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSBP1P2 grouped by PPP1R15A-low versus PPP1R15A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R15A→partner) and Y-score (partner→PPP1R15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HSBP1P2 →	+0.157	+4.276	.007	.008	3	2
UCEC	SKA1 →	+0.815	+3.831	<.001	<.001	3	2
UCEC	EME1 →	+0.648	+4.332	<.001	<.001	3	2
UCEC	METTL2B →	+0.470	+2.606	<.001	<.001	3	2
UCEC	BEST1 →	+0.296	+3.257	<.001	.008	3	2
UCEC	SPATA5L1 →	+0.513	+2.394	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,373 associations by consensus.

HSBP1P2 by PPP1R15A expression — CESC

Explore this box plot interactively →