PPP1R15A

Across TCGA patient cohorts, PPP1R15A mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R15A-associated genes across cancer lineages are eEF2, eIF4E, and A-Raf_pS299. Each is linked with PPP1R15A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R15A-to-partner and partner-to-PPP1R15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PPP1R15A-low versus PPP1R15A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R15A→partner) and Y-score (partner→PPP1R15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.471	+3.584	<.001	.002	3	1
UCEC	eIF4E →	+0.190	+3.169	.021	<.001	3	1
UCEC	A-Raf_pS299 →	-0.195	-2.222	<.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.122	-2.797	.013	.003	3	1
UCEC	GAPDH →	+0.488	+3.321	.020	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.154	-1.874	.020	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by PPP1R15A expression — UCEC

Explore this box plot interactively →