PPP1R15A

Across TCGA cell cohorts, PPP1R15A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,604 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPP1R15A-associated GO terms across cancer lineages are Positive regulation of miRNA metabolic process, Response to epidermal growth factor, and Regulation of extrinsic apoptotic signaling pathway via death domain receptors. Each is linked with PPP1R15A in more than 14 cancer types. Because this analysis shows association rather than direction, both PPP1R15A-to-partner and partner-to-PPP1R15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of miRNA metabolic process grouped by PPP1R15A-low versus PPP1R15A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R15A→partner) and Y-score (partner→PPP1R15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of miRNA metabolic process →	+0.123	+2.012	.001	<.001	3	15
BONE	Response to epidermal growth factor →	+0.140	+2.024	<.001	<.001	3	15
LIVER	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.147	+1.356	.005	.004	2	15
BONE	Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.645	+1.418	.001	<.001	3	14
BONE	Cellular response to epidermal growth factor stimulus →	+0.137	+1.606	.001	.004	3	14
LIVER	Canonical NF-kappaB signal transduction →	+0.107	+1.670	.006	.001	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,604 associations by consensus.

Positive regulation of miRNA metabolic process by PPP1R15A expression — BONE

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