PPP1R15A

Across TCGA cell cohorts, PPP1R15A mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPP1R15A-associated genes across cancer lineages are REG3A and H1-8. Each is linked with PPP1R15A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R15A-to-partner and partner-to-PPP1R15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3A grouped by PPP1R15A-low versus PPP1R15A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R15A→partner) and Y-score (partner→PPP1R15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG3A →	+0.028	+4.867	<.001	.009	3	1
CNS	H1-8 →	+0.022	+5.357	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

REG3A by PPP1R15A expression — BLOOD_Lymphoma

Explore this box plot interactively →