PPP1R14D

Across TCGA patient cohorts, PPP1R14D mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PPP1R14D-associated genes across cancer lineages are RNA5SP19, C1QBPP1, and USP9YP10. Each is linked with PPP1R14D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R14D-to-partner and partner-to-PPP1R14D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP19 grouped by PPP1R14D-low versus PPP1R14D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R14D→partner) and Y-score (partner→PPP1R14D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP19 →	+0.318	+4.867	<.001	.005	3	2
SKCM	C1QBPP1 →	+0.041	+4.771	<.001	.006	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1
LGG	MIR6854 →	+0.533	+7.977	<.001	.007	3	1
SKCM	RNA5SP92 →	+0.268	+4.680	<.001	.007	3	1
SKCM	GTF2IP11 →	+0.146	+4.680	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

RNA5SP19 by PPP1R14D expression — SKCM

Explore this box plot interactively →