PPP1R14B

Across TCGA pan-cancer cohorts, PPP1R14B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP1R14B data layer compared with 28 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPP1R14B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R14B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where PPP1R14B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.505	0.922	<.001	111	view →
PDAC	OS	Tertile	II,III,IV	0.344	0.600	.001	46	view →
UCEC	DFS	Median	II,III,IV	0.946	0.467	.002	24	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP1R14B–CCRCC (OS)

Open the CCRCC breakdown →