PPP1R14B

Across TCGA pan-cancer cohorts, PPP1R14B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PPP1R14B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP1R14B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1R14B is over-expressed in tumor.

HNSC, KIRC, and BLCA are the cancer types where PPP1R14B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R14B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.198	<.001	12	view →
KIRC	All	IV	+0.934	<.001	12	view →
BLCA	Male	IV	+2.187	<.001	11	view →
LUAD	Female	III,IV	+2.177	<.001	11	view →
KIRP	All	III,IV	+1.407	<.001	11	view →
COAD	Female	II,III,IV	+1.098	<.001	11	view →
STAD	Male	II,III,IV	+1.143	<.001	10	view →
LUSC	Male	III,IV	+2.567	<.001	9	view →
LIHC	Female	II,III,IV	+1.678	<.001	8	view →
THCA	Female	II,III,IV	+1.112	<.001	8	view →
KICH	All	All	+0.730	<.001	7	view →
UCEC	All	II,III,IV	+1.798	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PPP1R14B–HNSC

Open the HNSC breakdown →