PPP1R13B

Across TCGA patient cohorts, PPP1R13B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R13B-associated genes across cancer lineages are eEF2, NDRG1_pT346, and C-Raf. Each is linked with PPP1R13B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R13B-to-partner and partner-to-PPP1R13B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PPP1R13B-low versus PPP1R13B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R13B→partner) and Y-score (partner→PPP1R13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.316	+1.662	.012	.011	3	2
SKCM	NDRG1_pT346 →	-0.772	-2.321	.018	.035	3	2
UCEC	C-Raf →	+0.108	+1.362	.032	.037	3	2
UCEC	eIF4E →	+0.170	+2.000	.022	.030	3	1
UCEC	A-Raf_pS299 →	-0.142	-2.321	<.001	.033	3	1
UCEC	ERK2 →	+0.183	+2.807	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by PPP1R13B expression — UCEC

Explore this box plot interactively →