PPP1R13B

Across TCGA pan-cancer cohorts, PPP1R13B RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PPP1R13B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PPP1R13B RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R13B is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LIHC, and LUAD are the cancer types where PPP1R13B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R13B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.378	<.001	11	view →
LIHC	Female	II,III,IV	+0.785	<.001	7	view →
LUAD	All	II,III,IV	−0.619	<.001	7	view →
KIRC	Male	II,III,IV	−0.544	<.001	7	view →
CHOL	Male	All	+1.863	<.001	5	view →
LUSC	All	All	−0.482	<.001	4	view →
COAD	Female	All	−0.352	<.001	4	view →
PRAD	All	All	+0.266	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PPP1R13B–THCA

Open the THCA breakdown →