PPP1R12C

Across TCGA pan-cancer cohorts, PPP1R12C mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP1R12C data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP1R12C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R12C expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where PPP1R12C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.215	1.000	.008	32	view →
PDAC	OS	Tertile	All	0.558	0.279	.003	28	view →
CCRCC	DFS	Quartile	III,IV	0.680	0.174	.002	27	view →
GBM	DFS	Quartile	All	0.196	0.486	.007	11	view →
LSCC	DFS	Median	II,III,IV	0.529	0.856	.005	10	view →
LUAD	OS	Median	II,III,IV	0.893	0.453	.026	2	view →
HNSC	OS	Tertile	III,IV	0.597	0.836	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP1R12C–UCEC (DFS)

Open the UCEC breakdown →