PPP1R12C

Across TCGA cell cohorts, PPP1R12C mutation is significantly associated with the RNA expression of many other genes, with 850 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R12C-associated genes across cancer lineages are OR11H6, PRLHR, and NEUROD4. Each is linked with PPP1R12C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R12C-to-partner and partner-to-PPP1R12C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by PPP1R12C-low versus PPP1R12C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12C→partner) and Y-score (partner→PPP1R12C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H6 →	+0.028	+4.121	<.001	<.001	3	2
OVARY	PRLHR →	+0.018	+4.029	.004	.009	3	1
OVARY	NEUROD4 →	+0.011	+4.700	<.001	.002	3	1
CNS	BTNL3 →	+0.114	+3.774	<.001	.008	3	1
CNS	CBY2 →	+0.259	+3.774	<.001	.008	3	1
BREAST	GJA10 →	+0.022	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 850 associations by consensus.

OR11H6 by PPP1R12C expression — BLOOD_Leukemia

Explore this box plot interactively →