Across TCGA pan-cancer cohorts, PPP1R12BP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPP1R12BP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP1R12BP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R12BP1 is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and KIRC are the cancer types where PPP1R12BP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R12BP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.008	.010	4	view →
KIRP	All	All	−0.007	.004	4	view →
KIRC	All	III,IV	+0.007	.035	3	view →
BRCA	All	All	−0.006	.047	2	view →
LIHC	All	All	+0.005	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PPP1R12BP1 RNA expression & survival · all PPP1R12BP1 data types