PPP1R12A

Across TCGA pan-cancer cohorts, PPP1R12A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PPP1R12A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP1R12A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP1R12A is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where PPP1R12A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R12A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.207	<.001	11	view →
HNSC	All	III,IV	+0.114	<.001	11	view →
LSCC	Male	III,IV	−0.395	<.001	8	view →
LUAD	Male	III,IV	−0.370	<.001	8	view →
PDAC	Female	All	+0.496	<.001	6	view →
OV	All	All	−0.513	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PPP1R12A–COAD

Open the COAD breakdown →