PPP1R12A

Across TCGA patient cohorts, PPP1R12A mutation is significantly associated with the RNA expression of many other genes, with 5,227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R12A-associated genes across cancer lineages are RNU6-4P, MIR6779, and CCDC163. Each is linked with PPP1R12A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R12A-to-partner and partner-to-PPP1R12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-4P grouped by PPP1R12A-low versus PPP1R12A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12A→partner) and Y-score (partner→PPP1R12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-4P →	+0.510	+4.072	<.001	.005	3	3
BRCA	MIR6779 →	+0.591	+3.995	<.001	.001	3	2
UCEC	CCDC163 →	+0.422	+1.720	<.001	<.001	3	2
COAD	RNA5SP147 →	+0.219	+5.153	<.001	.001	3	2
BRCA	MTND4P19 →	+0.133	+4.347	<.001	.001	3	2
BRCA	RN7SL369P →	+0.373	+3.273	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,227 associations by consensus.

RNU6-4P by PPP1R12A expression — SKCM

Explore this box plot interactively →