PPP1R12A

Across TCGA patient cohorts, PPP1R12A mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R12A-associated genes across cancer lineages are PCNA, ASNS, and ATM. Each is linked with PPP1R12A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R12A-to-partner and partner-to-PPP1R12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PPP1R12A-low versus PPP1R12A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12A→partner) and Y-score (partner→PPP1R12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.153	+1.137	.024	.041	3	3
UCEC	ASNS →	+0.285	+1.584	.012	.017	3	2
UCEC	ATM →	-0.334	-2.308	.019	.033	3	2
UCEC	14-3-3_beta →	-0.065	-2.088	.040	.016	3	1
UCEC	eEF2 →	+0.257	+1.700	.022	.040	3	1
UCEC	EGFR_pY1068 →	-0.209	-1.836	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PCNA by PPP1R12A expression — UCEC

Explore this box plot interactively →