PPP1R12A

Across TCGA cell cohorts, PPP1R12A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,545 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP1R12A-associated GO terms across cancer lineages are Negative regulation of hippo signaling, Microtubule polymerization, and Protein localization to cytoskeleton. Each is linked with PPP1R12A in more than 15 cancer types. Because this analysis shows association rather than direction, both PPP1R12A-to-partner and partner-to-PPP1R12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hippo signaling grouped by PPP1R12A-low versus PPP1R12A-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12A→partner) and Y-score (partner→PPP1R12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of hippo signaling →	+0.105	+1.058	.001	<.001	3	16
LARGE_INTESTINE	Microtubule polymerization →	+0.123	+0.858	<.001	<.001	3	16
OVARY	Protein localization to cytoskeleton →	+0.075	+0.892	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Transcription elongation by RNA polymerase II →	+0.094	+0.989	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.072	+0.646	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol metabolic process →	+0.046	+0.985	.003	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,545 associations by consensus.

Negative regulation of hippo signaling by PPP1R12A expression — KIDNEY

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