PPP1R12A

Across TCGA cell cohorts, PPP1R12A mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R12A-associated genes across cancer lineages are F9, PHOX2B, and IGSF21. Each is linked with PPP1R12A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R12A-to-partner and partner-to-PPP1R12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by PPP1R12A-low versus PPP1R12A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12A→partner) and Y-score (partner→PPP1R12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	F9 →	+0.015	+4.321	<.001	<.001	3	1
CNS	PHOX2B →	+0.164	+4.154	.002	.001	3	1
CNS	IGSF21 →	+2.067	+3.906	<.001	.003	3	1
CNS	SV2C →	+1.344	+3.906	<.001	.002	3	1
CNS	TCF15 →	+0.671	+3.836	<.001	.003	3	1
CNS	MYOD1 →	+1.382	+3.684	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

F9 by PPP1R12A expression — CNS

Explore this box plot interactively →