PPP1R12A-AS1

Across TCGA pan-cancer cohorts, PPP1R12A-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPP1R12A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PPP1R12A-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R12A-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and COAD are the cancer types where PPP1R12A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R12A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.624	<.001	11	view →
KIRC	Male	II,III,IV	−0.585	<.001	10	view →
COAD	All	All	−0.300	<.001	10	view →
KICH	Female	II,III,IV	−1.228	<.001	8	view →
UCEC	All	All	−0.966	<.001	6	view →
BRCA	Female	All	−0.611	<.001	6	view →
KIRP	Male	All	−0.428	.001	5	view →
BLCA	Male	III,IV	−0.734	.010	4	view →
LUSC	All	All	−0.204	<.001	4	view →
HNSC	All	III,IV	+0.183	.005	4	view →
LUAD	Female	II,III,IV	−0.291	.008	3	view →
READ	All	All	−0.437	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPP1R12A-AS1–THCA

Open the THCA breakdown →