PPOX

Across TCGA patient cohorts, PPOX mutation is significantly associated with the RNA expression of many other genes, with 1,092 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPOX-associated genes across cancer lineages are RN7SL149P, H3P22, and MRPS15P1. Each is linked with PPOX in more than 1 cancer types. Because this analysis shows association rather than direction, both PPOX-to-partner and partner-to-PPOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL149P grouped by PPOX-low versus PPOX-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPOX→partner) and Y-score (partner→PPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL149P →	+0.090	+3.839	.009	.004	3	2
SKCM	H3P22 →	+0.214	+5.362	<.001	.005	3	2
CESC	MRPS15P1 →	+0.116	+3.413	<.001	.006	3	2
SKCM	RNY1P1 →	+0.384	+5.970	<.001	.002	3	2
UCEC	RNA5SP35 →	+0.273	+3.041	<.001	<.001	3	2
UCEC	RNU6-380P →	+0.144	+3.885	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,092 associations by consensus.

RN7SL149P by PPOX expression — CESC

Explore this box plot interactively →