Q-omics provides the consensus-scored H3P22 profile across patient tissues and cancer cell-line models. H3P22 expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in BLCA. Additionally, H3P22 RNA expression shows 6,097 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight BLCA, and STAD as cancer lineages where H3P22 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes H3P22 survival associations across molecular data types. H3P22 RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

H3P22 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	7	BLCA (90)	view →

This table ranks reproducible H3P22 RNA expression–survival associations across cancer types. High H3P22 expression shows unfavorable associations in BLCA, BRCA, LUAD, COAD and LIHC, but favorable associations in SKCM. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify BLCA as the clearest survival context for H3P22 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	IV	0.255	0.610	.002	90	view →
BRCA	OS	Tertile	All	0.899	0.963	.001	54	view →
LUAD	OS	Tertile	All	0.380	0.687	.008	45	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	36	view →
LIHC	OS	Tertile	All	0.276	0.707	.031	18	view →
SKCM	DFS	Tertile	III,IV	0.925	0.596	.021	12	view →

Pink = unfavorable, green = favorable. all 7 lineages →

H3P22-BLCA (OS)

Kaplan–Meier survival curve for H3P22 RNA expression in BLCA: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with H3P22 in patient tissues and cancer cell lines. In patient samples, H3P22 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	6,097	STAD (5715)	view →
RNA	4,654	HNSC (1479)	view →