PPOX

Across TCGA cell cohorts, PPOX mutation is significantly associated with the RNA expression of many other genes, with 322 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPOX-associated genes across cancer lineages are SRRM4, OR5G3, and BHLHE23. Each is linked with PPOX in more than 1 cancer types. Because this analysis shows association rather than direction, both PPOX-to-partner and partner-to-PPOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRRM4 grouped by PPOX-low versus PPOX-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPOX→partner) and Y-score (partner→PPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SRRM4 →	+0.629	+4.011	<.001	.009	3	1
PANCREAS	OR5G3 →	+0.032	+4.614	<.001	.004	3	1
OESOPHAGUS	BHLHE23 →	+0.255	+4.392	.002	.003	3	1
OESOPHAGUS	VSTM2B →	+0.129	+4.392	<.001	.003	3	1
LARGE_INTESTINE	DEPDC5 →	+0.605	+3.364	.002	.002	3	1
LARGE_INTESTINE	RNF125 →	+1.069	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 322 associations by consensus.

SRRM4 by PPOX expression — PANCREAS

Explore this box plot interactively →