Across TCGA patient cohorts, PPM1N mutation is significantly associated with the RNA expression of many other genes, with 503 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1N-associated genes across cancer lineages are IGKV2OR2-7, RN7SL248P, and LINC00158. Each is linked with PPM1N in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1N-to-partner and partner-to-PPM1N results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1N→partner) and Y-score (partner→PPM1N) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGKV2OR2-7 →	+0.463	+3.739	<.001	.003	3	2
UCEC	RN7SL248P →	+0.086	+3.722	<.001	.001	3	2
UCEC	LINC00158 →	+0.192	+3.424	.001	.007	3	2
UCEC	TRAJ47 →	+0.525	+2.520	<.001	.002	3	2
CESC	RNU6-934P →	+0.388	+5.669	<.001	.003	3	1
CESC	SNORD116-3 →	+0.543	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 503 associations by consensus.

Exploration

PPM1N survival (RNA) · tumor vs normal (RNA) · all PPM1N data types