PPM1L

Across TCGA pan-cancer cohorts, PPM1L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPM1L data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPM1L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1L expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, LUAD, and GBM are the cancer types where PPM1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.838	0.638	.004	34	view →
LUAD	DFS	Quartile	All	0.728	0.996	.003	14	view →
GBM	OS	Median	All	0.213	0.525	.004	5	view →
UCEC	DFS	Median	All	0.962	0.835	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPM1L–PDAC (DFS)

Open the PDAC breakdown →