PPM1L

Across TCGA patient cohorts, PPM1L RNA expression is significantly associated with the protein abundance of many other proteins, with 20,578 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPM1L-associated proteins across cancer lineages are EEPD1_S173, UNC13D, and PPP1R18_S368. Each is linked with PPM1L in more than 4 cancer types. Because this analysis shows association rather than direction, both PPM1L-to-partner and partner-to-PPM1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPM1L versus EEPD1_S173 in HNSC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1L→partner) and Y-score (partner→PPM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EEPD1_S173 →	+0.598	+1.056	<.001	<.001	3	5
GBM	UNC13D →	-0.482	-0.621	<.001	<.001	3	5
LSCC	PPP1R18_S368 →	-0.574	-0.878	<.001	<.001	3	5
LSCC	NCF1 →	-0.628	-0.934	<.001	<.001	3	4
GBM	NCF4 →	-0.597	-0.628	<.001	<.001	3	4
HNSC	OPTN →	-0.321	-0.791	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,578 associations by consensus.

PPM1L vs EEPD1_S173 — HNSC

Explore this scatter interactively →