PPM1L

Across TCGA patient cohorts, PPM1L protein abundance is significantly associated with the RNA expression of many other genes, with 9,857 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPM1L-associated genes across cancer lineages are GSTA4, QRICH2, and STXBP6. Each is linked with PPM1L in more than 3 cancer types. Because this analysis shows association rather than direction, both PPM1L-to-partner and partner-to-PPM1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPM1L versus GSTA4 in HNSC, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1L→partner) and Y-score (partner→PPM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GSTA4 →	+0.884	+0.411	.001	.001	3	4
HNSC	QRICH2 →	+0.775	+0.578	<.001	<.001	3	4
COAD	STXBP6 →	+0.882	+0.577	.001	.003	3	4
COAD	BCL2 →	+0.902	+0.870	.003	<.001	3	4
LSCC	ZADH2 →	+0.599	+0.545	<.001	<.001	3	4
UCEC	SMPD3 →	+1.049	+0.425	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,857 associations by consensus.

PPM1L vs GSTA4 — HNSC

Explore this scatter interactively →