PPM1L

Across TCGA cell cohorts, PPM1L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,423 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPM1L-associated GO terms across cancer lineages are Copper ion export, Negative regulation of T-helper cell differentiation, and Dentinogenesis. Each is linked with PPM1L in more than 11 cancer types. Because this analysis shows association rather than direction, both PPM1L-to-partner and partner-to-PPM1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Copper ion export grouped by PPM1L-low versus PPM1L-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1L→partner) and Y-score (partner→PPM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Copper ion export →	-0.228	-1.345	.002	.001	3	12
SOFT_TISSUE	Negative regulation of T-helper cell differentiation →	-0.134	-0.957	.002	.008	3	11
STOMACH	Dentinogenesis →	-1.269	-1.270	<.001	<.001	3	11
OESOPHAGUS	Regulation of potassium ion transport →	-0.101	-0.755	.003	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Heterochromatin organization →	+0.061	+1.431	.003	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.073	+1.421	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,423 associations by consensus.

Copper ion export by PPM1L expression — OESOPHAGUS

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