PPM1K-DT

Across TCGA pan-cancer cohorts, PPM1K-DT RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PPM1K-DT data layer.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher PPM1K-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1K-DT expression acts as an unfavorable survival marker, although some lineages such as CHOL and ESCA show a favorable association.

CHOL, ESCA, and CESC are the cancer types where PPM1K-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	DFS	Tertile	All	0.785	0.262	.001	44	view →
ESCA	OS	Tertile	III,IV	0.721	0.457	.011	39	view →
CESC	DFS	Quartile	II,III,IV	0.877	0.598	.005	38	view →
COAD	DFS	Median	All	0.417	0.599	.007	36	view →
LAML	DFS	Median	All	0.484	0.659	.003	36	view →
LUAD	OS	Median	All	0.895	0.768	<.001	36	view →
SKCM	DFS	Tertile	All	0.687	0.521	<.001	32	view →
ACC	OS	Quartile	II,III,IV	0.459	1.000	.007	21	view →
THYM	DFS	Quartile	All	0.781	0.972	.005	18	view →
MESO	OS	Quartile	IV	0.813	0.172	.006	18	view →
UCEC	DFS	Quartile	III,IV	0.707	0.846	.030	16	view →
READ	DFS	Median	All	0.578	0.791	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PPM1K-DT–CHOL (DFS)

Open the CHOL breakdown →