PPM1K-DT

Across TCGA pan-cancer cohorts, PPM1K-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PPM1K-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPM1K-DT RNA is repressed in tumor relative to normal tissue. In most cancer types PPM1K-DT is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where PPM1K-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1K-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.583	<.001	11	view →
HNSC	All	III,IV	−0.407	<.001	11	view →
KIRP	Male	All	−0.823	<.001	8	view →
KICH	Male	All	−1.043	<.001	7	view →
UCEC	All	II,III,IV	−0.961	<.001	6	view →
LUSC	Male	III,IV	−0.365	<.001	6	view →
STAD	All	All	−0.292	.007	5	view →
BLCA	All	All	−0.080	.013	5	view →
LUAD	Male	All	−0.182	.001	4	view →
BRCA	Female	II,III,IV	−0.131	.041	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PPM1K-DT–KIRC

Open the KIRC breakdown →