PPM1H

Across TCGA pan-cancer cohorts, PPM1H mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPM1H data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPM1H mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPM1H expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

LUAD, GBM, and PDAC are the cancer types where PPM1H mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.842	0.998	.005	22	view →
GBM	DFS	Median	All	0.832	0.657	.017	5	view →
PDAC	DFS	Tertile	III,IV	0.558	0.269	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PPM1H–LUAD (DFS)

Open the LUAD breakdown →