PPM1H

Across TCGA pan-cancer cohorts, PPM1H mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PPM1H’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PPM1H mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPM1H is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where PPM1H tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1H mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−1.100	<.001	11	view →
COAD	Female	III,IV	+0.703	<.001	10	view →
HNSC	Male	II,III,IV	−0.520	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PPM1H–CCRCC

Open the CCRCC breakdown →