PPM1G

Across TCGA cell cohorts, PPM1G mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPM1G-associated genes across cancer lineages are CLDN17, TEX26, and KRTAP20-2. Each is linked with PPM1G in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1G-to-partner and partner-to-PPM1G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN17 grouped by PPM1G-low versus PPM1G-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1G→partner) and Y-score (partner→PPM1G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLDN17 →	+0.018	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TEX26 →	+0.035	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP20-2 →	+0.269	+4.887	<.001	.009	3	1
BREAST	MYH8 →	+0.030	+5.781	<.001	.001	3	1
BREAST	FAM47B →	+0.016	+5.781	<.001	.001	3	1
LARGE_INTESTINE	CBY1 →	+0.791	+3.299	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

CLDN17 by PPM1G expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →