PPM1F

Across TCGA pan-cancer cohorts, PPM1F Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated PPM1F data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPM1F Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPM1F expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, BRCA, and MESO are the cancer types where PPM1F Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.392	0.744	<.001	35	view →
BRCA	OS	Median	All	0.669	0.924	.006	33	view →
MESO	OS	Median	II,III,IV	0.071	0.572	<.001	24	view →
COAD	OS	Median	All	0.172	0.870	<.001	18	view →
SKCM	DFS	Median	All	0.313	0.624	.002	16	view →
LIHC	OS	Median	All	0.152	0.688	.017	9	view →
TGCT	DFS	Median	All	0.040	0.837	<.001	6	view →
CESC	DFS	Median	All	0.496	0.824	.007	6	view →
STAD	DFS	Median	III,IV	0.060	0.585	<.001	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
KIRP	OS	Median	All	0.248	0.705	.049	2	view →
UCEC	DFS	Median	All	0.957	0.621	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

PPM1F–HNSC (OS)

Open the HNSC breakdown →