PPM1F

Across TCGA pan-cancer cohorts, PPM1F RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PPM1F’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPM1F RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPM1F is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

KIRC, LUAD, and LIHC are the cancer types where PPM1F tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1F RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.212	<.001	12	view →
LUAD	Female	III,IV	−1.351	<.001	11	view →
LIHC	Female	II,III,IV	+1.789	<.001	9	view →
THCA	All	II,III,IV	−0.476	<.001	9	view →
HNSC	All	All	+0.368	<.001	7	view →
UCEC	All	All	−1.394	<.001	6	view →
BRCA	All	III,IV	−1.160	<.001	6	view →
COAD	All	All	+0.365	<.001	6	view →
CHOL	Male	All	+2.271	<.001	5	view →
BLCA	All	IV	−0.828	.007	5	view →
LUSC	All	All	−0.603	<.001	4	view →
KIRP	All	All	−0.481	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PPM1F–KIRC

Open the KIRC breakdown →