PPM1F

Across TCGA pan-cancer cohorts, PPM1F mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPM1F data layer compared with 23 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPM1F mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1F expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where PPM1F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.889	0.286	.006	37	view →
CCRCC	DFS	Quartile	III,IV	0.875	0.342	.010	13	view →
LUAD	DFS	Tertile	All	0.906	0.402	.006	11	view →
PDAC	OS	Quartile	All	0.547	0.297	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPM1F–HNSC (DFS)

Open the HNSC breakdown →