PPM1F

Across TCGA patient cohorts, PPM1F mutation is significantly associated with the RNA expression of many other genes, with 913 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1F-associated genes across cancer lineages are CEP78, CENPU, and COX6CP5. Each is linked with PPM1F in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1F-to-partner and partner-to-PPM1F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP78 grouped by PPM1F-low versus PPM1F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1F→partner) and Y-score (partner→PPM1F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CEP78 →	+0.420	+2.732	.004	.003	3	3
UCEC	CENPU →	+0.601	+2.169	.002	<.001	3	3
BRCA	COX6CP5 →	+0.222	+6.268	<.001	.001	3	2
OV	RPL17P14 →	+0.078	+5.384	<.001	.005	3	2
HNSC	OR5M2P →	+0.096	+4.822	<.001	.006	3	2
SKCM	RNU6ATAC17P →	+0.557	+3.106	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 913 associations by consensus.

CEP78 by PPM1F expression — UCEC

Explore this box plot interactively →