PPM1F

Across TCGA patient cohorts, PPM1F mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1F-associated genes across cancer lineages are Shc_pY317, ERK2, and Acetyl-a-Tubulin-Lys40. Each is linked with PPM1F in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1F-to-partner and partner-to-PPM1F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by PPM1F-low versus PPM1F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1F→partner) and Y-score (partner→PPM1F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.149	-2.000	.007	.029	3	3
UCEC	ERK2 →	+0.186	+1.502	.008	.030	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.422	+1.847	.023	.008	3	2
UCEC	Annexin-1 →	+0.421	+2.459	.029	.018	3	2
UCEC	VHL →	-0.851	-2.115	<.001	.016	3	2
UCEC	Di-Ras3 →	-0.132	-2.571	.015	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Shc_pY317 by PPM1F expression — UCEC

Explore this box plot interactively →