PPM1F

Across TCGA cell cohorts, PPM1F mutation is significantly associated with the RNA expression of many other genes, with 326 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPM1F-associated genes across cancer lineages are TRMU, DDHD1, and CRYM. Each is linked with PPM1F in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1F-to-partner and partner-to-PPM1F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMU grouped by PPM1F-low versus PPM1F-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1F→partner) and Y-score (partner→PPM1F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRMU →	+0.704	+3.212	<.001	.006	3	1
LARGE_INTESTINE	DDHD1 →	+0.842	+3.212	.001	.006	3	1
LARGE_INTESTINE	CRYM →	+1.077	+3.212	.003	.006	3	1
LARGE_INTESTINE	SLC5A5 →	+0.242	+2.353	<.001	.008	3	1
LARGE_INTESTINE	GAR1 →	+0.558	+3.299	.002	.004	3	1
LARGE_INTESTINE	NEIL3 →	+0.834	+3.237	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 326 associations by consensus.

TRMU by PPM1F expression — LARGE_INTESTINE

Explore this box plot interactively →