PPM1E

Across TCGA pan-cancer cohorts, PPM1E Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPM1E data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPM1E Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1E expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, BRCA, and PRAD are the cancer types where PPM1E Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.849	0.619	.007	28	view →
BRCA	DFS	Median	All	0.412	0.903	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	II,III,IV	1.000	0.724	.023	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPM1E–UCEC (DFS)

Open the UCEC breakdown →