PPM1E

Across TCGA pan-cancer cohorts, PPM1E mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PPM1E data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PPM1E mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1E expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

GBM and CCRCC are the cancer types where PPM1E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.911	0.577	<.001	10	view →
CCRCC	DFS	Quartile	All	1.000	0.465	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PPM1E–GBM (DFS)

Open the GBM breakdown →