PPM1D

Across TCGA patient cohorts, PPM1D mutation is significantly associated with the RNA expression of many other genes, with 2,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1D-associated genes across cancer lineages are USP9YP10, SNORD3C, and RNA5SP68. Each is linked with PPM1D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1D-to-partner and partner-to-PPM1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP10 grouped by PPM1D-low versus PPM1D-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1D→partner) and Y-score (partner→PPM1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
SKCM	SNORD3C →	+0.030	+5.163	<.001	.002	3	2
HNSC	RNA5SP68 →	+0.545	+5.505	<.001	.004	3	2
HNSC	IGHVII-30-1 →	+0.186	+5.303	<.001	.006	3	2
COAD	MORF4L1P6 →	+0.277	+7.741	<.001	.009	3	2
SKCM	MIR1255B2 →	+0.275	+4.147	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,136 associations by consensus.

USP9YP10 by PPM1D expression — LGG

Explore this box plot interactively →