PPM1B

Across TCGA pan-cancer cohorts, PPM1B Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPM1B data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPM1B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPM1B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, KICH, and LUSC are the cancer types where PPM1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.219	0.684	.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LUSC	OS	Median	III,IV	0.178	0.683	.040	6	view →
UCEC	DFS	Median	All	0.958	0.891	.044	4	view →
SKCM	DFS	Median	II,III,IV	0.192	0.707	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPM1B–HNSC (DFS)

Open the HNSC breakdown →