PPM1B

Across TCGA pan-cancer cohorts, PPM1B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPM1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PPM1B RNA is repressed in tumor relative to normal tissue. In most cancer types PPM1B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where PPM1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.190	<.001	9	view →
LIHC	Male	All	+0.611	<.001	9	view →
THCA	All	II,III,IV	−0.501	<.001	9	view →
KIRC	Male	III,IV	−0.614	<.001	8	view →
COAD	All	All	−0.299	<.001	8	view →
READ	All	All	−0.426	.001	5	view →
STAD	All	II,III,IV	+0.456	.012	3	view →
CHOL	All	All	+0.972	<.001	2	view →
PAAD	Female	All	−0.529	.022	2	view →
KIRP	Male	All	−0.487	.002	2	view →
ESCA	Female	All	+0.696	.036	1	view →
HNSC	All	III,IV	+0.398	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPM1B–KICH

Open the KICH breakdown →