PPM1B

Across TCGA pan-cancer cohorts, PPM1B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPM1B data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPM1B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPM1B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, HNSC, and OV are the cancer types where PPM1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.939	0.688	.001	50	view →
HNSC	DFS	Median	All	0.361	0.860	.030	12	view →
OV	DFS	Tertile	All	0.535	0.864	.025	8	view →
GBM	OS	Median	All	0.935	0.781	.006	7	view →
LSCC	OS	Median	All	0.927	0.820	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPM1B–CCRCC (OS)

Open the CCRCC breakdown →