PPM1B

Across TCGA patient cohorts, PPM1B protein abundance is significantly associated with the RNA expression of many other genes, with 3,619 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PPM1B-associated genes across cancer lineages are SRBD1, SGIP1, and ABL2. Each is linked with PPM1B in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1B-to-partner and partner-to-PPM1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPM1B versus SRBD1 in HNSC, with a Pearson correlation of 0.25.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1B→partner) and Y-score (partner→PPM1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SRBD1 →	+0.485	+0.232	<.001	<.001	3	3
COAD	SGIP1 →	-0.521	-0.377	.002	.001	3	2
COAD	ABL2 →	-0.428	-0.242	.003	.004	3	2
HNSC	LINC00476 →	+0.466	+0.170	.001	.009	3	2
CCRCC	MIR4427 →	-0.882	-0.192	.002	.003	3	2
CCRCC	YBX3 →	-0.646	-0.247	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,619 associations by consensus.

PPM1B vs SRBD1 — HNSC

Explore this scatter interactively →