PPM1B

Across TCGA patient cohorts, PPM1B mutation is significantly associated with the RNA expression of many other genes, with 4,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1B-associated genes across cancer lineages are MIR4790, RNU6-494P, and RN7SL837P. Each is linked with PPM1B in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1B-to-partner and partner-to-PPM1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4790 grouped by PPM1B-low versus PPM1B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1B→partner) and Y-score (partner→PPM1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4790 →	+0.266	+5.339	<.001	.001	3	3
SKCM	RNU6-494P →	+0.285	+4.469	<.001	.006	3	3
SKCM	RN7SL837P →	+0.089	+4.993	<.001	.002	3	2
CESC	MIR194-1 →	+0.519	+4.069	.001	.005	3	2
UCEC	OXA1L →	+0.301	+2.290	<.001	<.001	3	2
UCEC	SSU72 →	+0.217	+2.021	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

MIR4790 by PPM1B expression — LUAD

Explore this box plot interactively →