PPM1B

Across TCGA cell cohorts, PPM1B mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPM1B-associated genes across cancer lineages are PTH2R, ACER1, and OR10A4. Each is linked with PPM1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1B-to-partner and partner-to-PPM1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH2R grouped by PPM1B-low versus PPM1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1B→partner) and Y-score (partner→PPM1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTH2R →	+0.945	+3.716	<.001	.003	3	1
LARGE_INTESTINE	ACER1 →	+0.087	+3.145	.001	.004	3	1
LARGE_INTESTINE	OR10A4 →	+0.045	+2.938	.007	.007	3	1
LARGE_INTESTINE	OR4F21 →	+0.174	+4.141	<.001	<.001	3	1
LARGE_INTESTINE	OR2T8 →	+0.133	+3.584	.007	.004	3	1
LARGE_INTESTINE	OR2W3 →	+0.802	+3.355	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PTH2R by PPM1B expression — LARGE_INTESTINE

Explore this box plot interactively →