PPIP5K1

Across TCGA patient cohorts, PPIP5K1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIP5K1-associated genes across cancer lineages are STAT3_pY705, CD49b, and IRS1. Each is linked with PPIP5K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIP5K1-to-partner and partner-to-PPIP5K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PPIP5K1-low versus PPIP5K1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIP5K1→partner) and Y-score (partner→PPIP5K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.393	-2.459	.001	.020	3	2
UCEC	CD49b →	-0.327	-3.150	.017	.019	3	2
UCEC	IRS1 →	+0.236	+2.459	.018	.020	3	1
UCEC	PDCD4 →	-0.693	-2.999	.002	.035	3	1
UCEC	Chk2 →	-0.232	-2.459	.040	.020	3	1
UCEC	p62 Lck ligand →	+0.460	+3.009	.003	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

STAT3_pY705 by PPIP5K1 expression — UCEC

Explore this box plot interactively →