PPIP5K1

Across TCGA pan-cancer cohorts, PPIP5K1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PPIP5K1 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PPIP5K1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PPIP5K1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and BRCA show a favorable association.

KIRP, OV, and BRCA are the cancer types where PPIP5K1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.921	0.718	.001	60	view →
OV	OS	Tertile	All	0.296	0.424	.003	42	view →
BRCA	DFS	Quartile	III,IV	0.935	0.806	.006	22	view →
COAD	DFS	Median	III,IV	0.329	0.526	.008	17	view →
ACC	DFS	Quartile	III,IV	0.782	0.145	.012	14	view →
LUSC	DFS	Median	III,IV	0.526	0.914	.011	12	view →
SKCM	OS	Median	All	0.823	0.739	.001	11	view →
READ	OS	Quartile	II,III,IV	0.935	0.477	.024	10	view →
BLCA	OS	Quartile	All	0.828	0.667	.007	9	view →
UVM	DFS	Median	All	0.849	0.627	.017	9	view →
CESC	DFS	Quartile	III,IV	0.587	0.915	.014	4	view →
KIRC	DFS	Tertile	III,IV	0.619	0.376	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PPIP5K1–KIRP (OS)

Open the KIRP breakdown →